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Validation for Tricyclic Antidepressants in Pharmaceutical Dosage Forms

Validation for Tricyclic Antidepressants in Pharmaceutical Dosage Forms

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  • ISBN-13: 9781544766997
  • Publisher: CreateSpace Independent Publishing Platform
  • Release Date: Mar 18, 2017
  • Pages: 108 pages
  • Dimensions: 0.25 x 11.0 x 8.5 inches
  • Sales Rank: 0

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Overview

Hafliger and Schindler in the late 1940s synthesized a seriese of more than 40 iminobenzyl derivatives for possible use as antihistamines, sedatives, analgesics, and antiparkinsonian drugs. One of these was imipramine, a dibenzazepine compound, which differs from the phenothiazines only by replacement of the sulfur with an ethylene bridge to produce a seven membered central ring analogous to the benzazepine antipsychotic agents. Following screening in animals, a few compounds, including imipramine, were selected on the basis of sedative or hypnotic properties for therapeutic trial.

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