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Mnogokomponentnye geterotsiklizatsii s upravlyaemoy selektivnost'yu: Reaktsii karbonil'nykh soedineniy s azotsoderzhashchimi mono-, bi- i polinukleofilami

Mnogokomponentnye geterotsiklizatsii s upravlyaemoy selektivnost'yu: Reaktsii karbonil'nykh soedineniy s azotsoderzhashchimi mono-, bi- i polinukleofilami

Regular price $131.43
  • ISBN-13: 9783843322973
  • Publisher: Betascript Publishing
  • Release Date: Apr 21, 2011
  • Pages: 340 pages
  • Dimensions: 0.77 x 8.66 x 5.91 inches

Overview

Monografiya posvyashchena mnogokomponentnym reaktsiyam karbonil'nykh soedineniy s mono-, bi- i polinukleofilami, ustanovleniyu ikh zakonomernostey, svyazi mezhdu reaktsionnymi parametrami, strukturoy reagiruyushchikh veshchestv i napravleniem geterotsiklizatsiy. Razrabotany osnovy strategii upravleniya napravlennost'yu vzaimodeystviy, v tom chisle s primeneniem mikrovolnovogo i ul'trazvukovogo izlucheniya. Ustanovlena vozmozhnost' prokhozhdeniya izuchaemykh reaktsiy pod kineticheskim ili pod termodinamicheskim kontrolem, chto pozvolyaet var'irovaniem temperatury upravlyat' ikh napravleniem. Izucheno vliyanie kislotno-osnovnykh svoystv reaktsionnoy sredy i tipa ispol'zuemoy kataliticheskoy sistemy na sostav produktov geterotsiklizatsiy. Otkryt ryad novykh mnogokomponentnykh reaktsiy, privodyashchikh, v chastnosti, k obrazovaniyu ranee neopisannykh analogov prirodnykh alkaloidov, soderzhashchikh khinolizinovyy fragment, a tak zhe k formirovaniyu novogo klassa spirogeterotsiklov. Provedeny issledovaniya termicheskikh i fotokhimicheskikh reaktsiy bi- i tritsiklicheskikh aziridinov, vydvinuta gipoteza ob uchastii v nikh stabil'nykh tripletnykh biradikal'nykh chastits. Provedeny in vitro i in vivo issledovaniya biologicheskoy aktivnosti ryada poluchennykh soedineniy.

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