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Thiocillin I: Total Synthesis and Complete Structural Assignment

Thiocillin I: Total Synthesis and Complete Structural Assignment

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  • ISBN-13: 9783844391008
  • Publisher: LAP LAMBERT Academic Publishing
  • Release Date: May 05, 2011
  • Pages: 172 pages
  • Dimensions: 0.39 x 8.66 x 5.91 inches

Overview

Over the past half century, the absolute configuration of thiopeptide antibiotics such as Thiocillin I has baffled chemists until the first correct synthesis of Micrococcin P1 in 2009. At this point we had to answer two questions - first, does the absolute configuration hold true for its natural analogues? Second, can we design a more efficient synthesis of the tri-substituted pyridine core? The current synthesis sheds light on these problems especially for medicinal chemists who wish to explore the SAR for the purposes of drug development.

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